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Identification and characterization of host proteins bound to dengue virus 3′ UTR reveal an antiviral role for quaking proteins

23 Mar 2018

Abstract excerpt

The four dengue viruses (DENV1-4) are rapidly reemerging infectious RNA viruses. These positive-strand viral genomes contain structured 3' untranslated regions (UTRs) that interact with various host RNA binding proteins (RBPs). These RBPs are functionally important in viral replication, pathogenesis, and defense against host immune mechanisms. Here, we combined RNA chromatography and quantitative mass...

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PMID: 29572260
DOI: 10.1261/rna.064006.117

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