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Article

Germline Variants in the POT1-Gene in High-Risk Melanoma Patients in Austria.

G3 (Bethesda, Md.) - 4 May 2018

Müller Christoph, Krunic Milica, Wendt Judith, von Haeseler Arndt, Okamoto Ichiro

Abstract excerpt

Risk of melanoma is in part determined by genetic factors. Currently the only established high penetrance familial melanoma genes are CDKN2A and CDK4. Recent studies reported germline variants in POT1 in melanoma families. In the present study, we sequenced the entire POT1 gene in 694 patients from the M3-study. Patients with multiple primary melanomas (n = 163) or with a positive family history (n = 133) were...

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Source

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Identifiers

PMID: 29523635
DOI: 10.1534/g3.117.300394
PMCID: PMC5940141

Genes

POT1
CDK4

Provenance

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