Article
PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53.
Oncogene - 1 May 2018
Liu Qi, Gheorghiu Liliana, Drumm Michael, Clayman Rebecca, Eidelman Alec, Wszolek Matthew F, Olumi Aria, Feldman Adam, Wang Meng, Marcar Lynnette, Citrin Deborah E, Wu Chin-Lee, Benes Cyril H, Efstathiou Jason A, Willers Henning
Abstract excerpt
Biomarkers and mechanisms of poly (ADP-ribose) polymerase (PARP) inhibitor-mediated cytotoxicity in tumor cells lacking a BRCA-mutant or BRCA-like phenotype are poorly defined. We sought to explore the utility of PARP-1 inhibitor (PARPi) treatment with/without ionizing radiation in muscle-invasive bladder cancer (MIBC), which has poor therapeutic outcomes. We assessed the DNA damaging and cytotoxic effects of the...
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