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Bumetanide for autism: more eye contact, less amygdala activation

20 Feb 2018

Abstract excerpt

We recently showed that constraining eye contact leads to exaggerated increase of amygdala activation in autism. Here, in a proof of concept pilot study, we demonstrate that administration of bumetanide (a NKCC1 chloride importer antagonist that restores GABAergic inhibition) normalizes the level of amygdala activation during constrained eye contact with dynamic emotional face stimuli in autism. In addition,...

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PMID: 29483603
DOI: 10.1038/s41598-018-21958-x

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