Article
Considerations for Developing Targeted Therapies in Low-Frequency Molecular Subsets of a Disease.
Clinical pharmacology and therapeutics - 1 Aug 2018
Schuck Robert N, Woodcock Janet, Zineh Issam, Stein Peter, Jarow Jonathan, Temple Robert, Permutt Thomas, LaVange Lisa, Beaver Julia A, Charlab Rosane, Blumenthal Gideon M, Dorff Sarah E, Leptak Christopher, Lemery Steven, Rogers Hobart, Chowdhury Badrul, Litwack E David, Pacanowski Michael
Abstract excerpt
Advances in our understanding of the molecular underpinnings of disease have spurred the development of targeted therapies and the use of precision medicine approaches in patient care. While targeted therapies have improved our capability to provide effective treatments to patients, they also present additional challenges to drug development and benefit-risk assessment such as identifying the subset(s) of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.