Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

doi:10.1038/s41556-018-0040-4

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Article

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

Nature cell biology - 1 Mar 2018

Zhang Haiying, Freitas Daniela, Kim Han Sang, Fabijanic Kristina, Li Zhong, Chen Haiyan, Mark Milica Tesic, Molina Henrik, Martin Alberto Benito, Bojmar Linda, Fang Justin, Rampersaud Sham, Hoshino Ayuko, Matei Irina, Kenific Candia M, Nakajima Miho, Mutvei Anders Peter, Sansone Pasquale, Buehring Weston, Wang Huajuan, Jimenez Juan Pablo, Cohen-Gould Leona, Paknejad Navid, Brendel Matthew, Manova-Todorova Katia, Magalhães Ana, Ferreira José Alexandre, Osório Hugo, Silva André M, Massey Ashish, Cubillos-Ruiz Juan R, Galletti Giuseppe, Giannakakou Paraskevi, Cuervo Ana Maria, Blenis John, Schwartz Robert, Brady Mary Sue, Peinado Héctor, Bromberg Jacqueline, Matsui Hiroshi, Reis Celso A, Lyden David

Abstract excerpt

The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Exo-S, 60-80 nm) and discovered an abundant population of non-membranous nanoparticles termed...

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PMID: 29459780
DOI: 10.1038/s41556-018-0040-4
PMCID: PMC5931706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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