Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.

doi:10.1038/s41588-018-0056-5

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Article

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.

Nature genetics - 1 Mar 2018

Bouwman Aniek C, Daetwyler Hans D, Chamberlain Amanda J, Ponce Carla Hurtado, Sargolzaei Mehdi, Schenkel Flavio S, Sahana Goutam, Govignon-Gion Armelle, Boitard Simon, Dolezal Marlies, Pausch Hubert, Brøndum Rasmus F, Bowman Phil J, Thomsen Bo, Guldbrandtsen Bernt, Lund Mogens S, Servin Bertrand, Garrick Dorian J, Reecy James, Vilkki Johanna, Bagnato Alessandro, Wang Min, Hoff Jesse L, Schnabel Robert D, Taylor Jeremy F, Vinkhuyzen Anna A E, Panitz Frank, Bendixen Christian, Holm Lars-Erik, Gredler Birgit, Hozé Chris, Boussaha Mekki, Sanchez Marie-Pierre, Rocha Dominique, Capitan Aurelien, Tribout Thierry, Barbat Anne, Croiseau Pascal, Drögemüller Cord, Jagannathan Vidhya, Vander Jagt Christy, Crowley John J, Bieber Anna, Purfield Deirdre C, Berry Donagh P, Emmerling Reiner, Götz Kay-Uwe, Frischknecht Mirjam, Russ Ingolf, Sölkner Johann, Van Tassell Curtis P, Fries Ruedi, Stothard Paul, Veerkamp Roel F, Boichard Didier, Goddard Mike E, Hayes Ben J

Abstract excerpt

Stature is affected by many polymorphisms of small effect in humans 1 . In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed...

Topics

Animals
Body Height
Body Size
Cattle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Conserved Sequence

Genetic Association Studies

Genetic Variation

Genome-Wide Association Study

Humans

Mammals

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Open in PubMed

Identifiers

PMID: 29459679
DOI: 10.1038/s41588-018-0056-5

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