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Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

25 Jan 2018

Abstract excerpt

Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representation bisulfite sequencing (RRBS), we, respectively, investigated sRNA expression and DNA methylation in pure fractions of...

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PMID: 29416570
DOI: 10.1186/s13148-018-0446-7

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