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Article

MinC and FtsZ mutant analysis provides insight into MinC/MinD-mediated Z ring disassembly.

The Journal of biological chemistry - 20 Apr 2018

Park Kyung-Tae, Dajkovic Alex, Wissel Mark, Du Shishen, Lutkenhaus Joe

Abstract excerpt

The Min system negatively regulates the position of the Z ring, which serves as a scaffold for the divisome that mediates bacterial cytokinesis. In Escherichia coli, this system consists of MinC, which antagonizes assembly of the tubulin homologue FtsZ. MinC is recruited to the membrane by MinD and induced by MinE to oscillate between the cell poles. MinC is a dimer with each monomer consisting of functionally...

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Identifiers

PMID: 29414773
DOI: 10.1074/jbc.M117.815894
PMCID: PMC5912481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MinC and FtsZ mutant analysis provides insight into MinC/MinD-mediated Z ring disassembly.PMID 29414773Read ↗

The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization.Semantic proximity Read ↗

MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component.Semantic proximity Read ↗

MinC/MinD copolymers are not required for Min function.Semantic proximity Read ↗

Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring.Semantic proximity Read ↗

Escherichia coli division inhibitor MinCD blocks septation by preventing Z-ring formation.Semantic proximity Read ↗

Deletion of the min operon results in increased thermosensitivity of an ftsZ84 mutant and abnormal FtsZ ring assembly, placement, and disassembly.Semantic proximity Read ↗

Genetic and biochemical characterization of the MinC-FtsZ interaction in Bacillus subtilis.Semantic proximity Read ↗

MinCD cell division proteins form alternating copolymeric cytomotive filaments.Semantic proximity Read ↗

Bacillus subtilis MinC destabilizes FtsZ-rings at new cell poles and contributes to the timing of cell division.Semantic proximity Read ↗

Clostridial DivIVA and MinD interact in the absence of MinJ.Semantic proximity Read ↗

Roles of MinC and MinD in the site-specific septation block mediated by the MinCDE system of Escherichia coli.Semantic proximity Read ↗

The switch I and II regions of MinD are required for binding and activating MinC.Semantic proximity Read ↗

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