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Immunosuppressants produced by Streptomyces : evolution, hygiene hypothesis, tumour rapalog resistance and probiotics

26 Jan 2018

Abstract excerpt

Resistance to a drug and the suppression of inflammatory disorders with immunosuppressive drugs might have happened upon exposure to natural compounds during evolution. Streptomycetes are soil bacteria, but they produce therapeutic drugs. They have been reported to be the low-abundant members of mucosal microbiomes with a higher prevalence in nonhumans ingesting soil compared with humans. Their lower abundance in...

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PMID: 29377607
DOI: 10.1111/1758-2229.12617

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