The silent healer: miR-205-5p up-regulation inhibits epithelial to mesenchymal transition in colon cancer cells by indirectly up-regulating E-cadherin expression.

doi:10.1038/s41419-017-0102-8

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Article

The silent healer: miR-205-5p up-regulation inhibits epithelial to mesenchymal transition in colon cancer cells by indirectly up-regulating E-cadherin expression.

Cell death & disease - 19 Jan 2018

Gulei Diana, Magdo Lorand, Jurj Ancuta, Raduly Lajos, Cojocneanu-Petric Roxana, Moldovan Alin, Moldovan Cristian, Florea Adrian, Pasca Sergiu, Pop Laura-Ancuta, Moisoiu Vlad, Budisan Liviuta, Pop-Bica Cecilia, Ciocan Cristina, Buiga Rares, Muresan Mihai-Stefan, Stiufiuc Rares, Ionescu Calin, Berindan-Neagoe Ioana

Abstract excerpt

EMT represents the dominant program within advanced stages of colon cancer, where cells acquire migratory characteristics in order to invade secondary tissues and form metastasis. Where the majority of the therapeutic strategies are concentrated on the reduction of the tumor mass through different apoptotic mechanisms, the present study advocates an important role for miR-205-5p in impairment of colon cancer...

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PMID: 29352232
DOI: 10.1038/s41419-017-0102-8
PMCID: PMC5833765

Genes

CDH1
ZEB1

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