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Article

Hypermutated Tumors and Immune Checkpoint Inhibition.

Drugs - 1 Feb 2018

Ciombor Kristen K, Goldberg Richard M

Abstract excerpt

Microsatellite instability-high/DNA mismatch repair deficient tumors are found across the cancer spectrum and often harbor markedly increased numbers of mutations when compared to microsatellite stable/DNA mismatch repair proficient tumors. As a result of this high mutational load, tumor-infiltrating lymphocyte density is increased and more immunogenic neoepitopes are expressed, leading to upregulation of immune...

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Share to Antibodies, Monoclonal, Humanized
Share to Antineoplastic Agents, Immunological
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplastic Syndromes, Hereditary

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Source

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Identifiers

PMID: 29350327
DOI: 10.1007/s40265-018-0863-0
PMCID: PMC10184712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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