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A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer

8 Jan 2018

Abstract excerpt

Long non-coding RNAs (lncRNAs) have been implicated in human pathology, however, their role in colorectal carcinogenesis have not been fully elucidated. In the current study, whole-transcriptome analysis was performed in 3 pairs of colorectal cancer (CRC) and matched normal mucosa (NM) by RNA sequencing (RNA-seq). Followed by confirmation using the Cancer Genome Atlas (TCGA) dataset, we identified 27 up-regulated...

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PMID: 29330370
DOI: 10.1038/s41598-017-18407-6

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