Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA.

doi:10.1158/1078-0432.CCR-17-1341

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Article

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2018

Goldberg Sarah B, Narayan Azeet, Kole Adam J, Decker Roy H, Teysir Jimmitti, Carriero Nicholas J, Lee Angela, Nemati Roxanne, Nath Sameer K, Mane Shrikant M, Deng Yanhong, Sukumar Nitin, Zelterman Daniel, Boffa Daniel J, Politi Katerina, Gettinger Scott N, Wilson Lynn D, Herbst Roy S, Patel Abhijit A

Abstract excerpt

Purpose: Decisions to continue or suspend therapy with immune checkpoint inhibitors are commonly guided by tumor dynamics seen on serial imaging. However, immunotherapy responses are uniquely challenging to interpret because tumors often shrink slowly or can appear transiently enlarged due to inflammation. We hypothesized that monitoring tumor cell death in real time by quantifying changes in circulating tumor...

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PMID: 29330207
DOI: 10.1158/1078-0432.CCR-17-1341
PMCID: PMC5899677

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