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Article

Novel Molecular and Phenotypic Insights into Congenital Lung Malformations.

American journal of respiratory and critical care medicine - 15 May 2018

Swarr Daniel T, Peranteau William H, Pogoriler Jennifer, Frank David B, Adzick N Scott, Hedrick Holly L, Morley Mike, Zhou Su, Morrisey Edward E

Abstract excerpt

RATIONALE: Disruption of normal pulmonary development is a leading cause of morbidity and mortality in infants. Congenital lung malformations are a unique model to study the molecular pathogenesis of isolated structural birth defects, as they are often surgically resected. OBJECTIVES: To provide insight into the molecular pathogenesis of congenital lung malformations through analysis of cell-type and gene...

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PMID: 29328793
DOI: 10.1164/rccm.201706-1243OC
PMCID: PMC5955056

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