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Article

Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women.

Nutrients - 9 Jan 2018

Chandler Paulette D, Tobias Deirdre K, Wang Lu, Smith-Warner Stephanie A, Chasman Daniel I, Rose Lynda, Giovannucci Edward L, Buring Julie E, Ridker Paul M, Cook Nancy R, Manson JoAnn E, Sesso Howard D

Abstract excerpt

Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29315215
DOI: 10.3390/nu10010055
PMCID: PMC5793283

Genes

DHCR7

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