Article
Activation of Rab GTPase Sec4 by its GEF Sec2 is required for prospore membrane formation during sporulation in yeast Saccharomyces cerevisiae.
FEMS yeast research - 1 Feb 2018
Suda Yasuyuki, Tachikawa Hiroyuki, Inoue Ichiro, Kurita Tomokazu, Saito Chieko, Kurokawa Kazuo, Nakano Akihiko, Irie Kenji
Abstract excerpt
Sec2 activates Sec4 Rab GTPase as a guanine nucleotide exchange factor for the recruitment of downstream effectors to facilitate tethering and fusion of post-Golgi vesicles at the plasma membrane. During the meiosis and sporulation of budding yeast, post-Golgi vesicles are transported to and fused at the spindle pole body (SPB) to form a de novo membrane, called the prospore membrane. Previous studies have...
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