Article
Adaptation or pathology? The role of prenatal stressor type and intensity in the developmental programing of adult phenotype.
Neurotoxicology and teratology - 1 Jan 2000
St-Cyr Sophie, McGowan Patrick O
Abstract excerpt
The mother is the major interface between the offspring and its prenatal environment. Prenatal toxins and stress-inducing physical agents are important factors programming the developmental trajectory of mammals that likely involve epigenetic modifications. However, prenatal stressors commonly-used in the laboratory (e.g. prenatal restraint stress and prenatal chronic variable stress) are typically administered...
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