Article
Response rates to single-agent chemotherapy after exposure to immune checkpoint inhibitors in advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2017
Schvartsman Gustavo, Peng S Andrew, Bis Giorgios, Lee J Jack, Benveniste Marcelo F K, Zhang Jianjun, Roarty Emily B, Lacerda Lara, Swisher Stephen, Heymach John V, Fossella Frank V, William William N
Abstract excerpt
INTRODUCTION: Exploratory analysis of clinical trials in various tumor types have demonstrated potential improvements in overall response rate (ORR) to chemotherapy after exposure to vaccine-based immunotherapy. The objective of this retrospective study was to determine if single-agent chemotherapy (3rd-line or beyond) would yield improved ORR when given after exposure to programmed death-(ligand)1 inhibitors...
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