Does EGFR Mutation Type Influence Patient-Reported Outcomes in Patients with Advanced EGFR Mutation-Positive Non-Small-Cell Lung Cancer? Analysis of Two Large, Phase III Studies Comparing Afatinib with Chemotherapy (LUX-Lung 3 and LUX-Lung 6).

doi:10.1007/s40271-017-0287-z

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Does EGFR Mutation Type Influence Patient-Reported Outcomes in Patients with Advanced EGFR Mutation-Positive Non-Small-Cell Lung Cancer? Analysis of Two Large, Phase III Studies Comparing Afatinib with Chemotherapy (LUX-Lung 3 and LUX-Lung 6).

The patient - 1 Feb 2018

Wu Yi-Long, Hirsh Vera, Sequist Lecia V, Hu Cheng-Ping, Feng Jifeng, Lu Shun, Huang Yunchao, Schuler Martin, Mok Tony, Yamamoto Nobuyuki, O'Byrne Kenneth, Geater Sarayut L, Zhou Caicun, Massey Dan, Märten Angela, Lungershausen Juliane, Yang James Chih-Hsin

Abstract excerpt

INTRODUCTION: In LUX-Lung 3 and LUX-Lung 6, afatinib significantly improved progression-free survival (PFS) versus chemotherapy in patients with tumors harboring common epidermal growth factor receptor (EGFR) mutations (Del19/L858R) and significantly improved overall survival (OS) in patients with tumors harboring Del19 mutations. Patient-reported outcomes stratified by EGFR mutation type are reported. PATIENTS...

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PMID: 29178024
DOI: 10.1007/s40271-017-0287-z
PMCID: PMC5766712

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Does EGFR Mutation Type Influence Patient-Reported Outcomes in Patients with Advanced EGFR Mutation-Positive Non-Small-Cell Lung Cancer? Analysis of Two Large, Phase III Studies Comparing Afatinib with Chemotherapy (LUX-Lung 3 and LUX-Lung 6).PMID 29178024Read ↗

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