Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?

25 Nov 2017

Abstract excerpt

A prospective first-in-human Phase 1 CRISPR gene editing trial in the United States for patients with melanoma, synovial sarcoma, and multiple myeloma offers hope that gene editing tools may usefully treat human disease. An overarching ethical challenge with first-in-human Phase 1 clinical trials, however, is knowing when it is ethically acceptable to initiate such trials on the basis of safety and efficacy data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Ethics and Regulation
Share to CRISPR and Genetic Engineering

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29173170
DOI: 10.2174/1566523217666171121165935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?PMID 29173170Read ↗

Evaluating the First-in-Human Clinical Trial of a Human Embryonic Stem Cell-Based TherapySemantic proximity Read ↗

Immunity to CRISPR Cas9 and Cas12a therapeuticsSemantic proximity Read ↗

First CRISPR clinical trial gets green light from US panelSemantic proximity Read ↗

Crowdsourcing the Moral Limits of Human Gene Editing?Semantic proximity Read ↗

The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancerSemantic proximity Read ↗

Debating Ethical Issues in Genome Editing TechnologySemantic proximity Read ↗

Initial heritable genome editing: mapping a responsible pathway from basic research to the clinicSemantic proximity Read ↗

Justice in CRISPR/Cas9 Research and Clinical ApplicationsSemantic proximity Read ↗

Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing.Semantic proximity Read ↗

Gene Transfer and the Ethics of First-in-Human Research: Lost in TranslationSemantic proximity Read ↗

CRISPR Gene-Therapy: A Critical Review of Ethical Concerns and a Proposal for Public Decision-MakingSemantic proximity Read ↗

The Human Right to Science and the Regulation of Human Germline EngineeringSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.