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Article

Down-regulation of miR-378a-3p induces decidual cell apoptosis: a possible mechanism for early pregnancy loss

28 Oct 2017

Abstract excerpt

STUDY QUESTION: Do microRNAs (miRNAs) contribute to human early pregnancy loss (EPL)? SUMMARY ANSWER: miR-378a-3p expression is regulated by progesterone and is down-regulated in ducidua of EPL patients which may contribute to decidual apoptosis through Caspase-3 activation. WHAT IS KNOWN ALREADY: A variety of miRNAs have been demonstrated to be associated with the development of decidualization and placental...

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PMID: 29165645
DOI: 10.1093/humrep/dex347

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