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Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses

9 Nov 2017

Abstract excerpt

ABSTRACT Multiple hereditary exostoses (MHE), also known as multiple osteochondromas (MO), is an autosomal dominant disorder characterized by the development of multiple cartilage-capped bone tumors (osteochondromas). The large majority of patients with MHE carry loss-of-function mutations in the EXT1 or EXT2 gene, which encodes a glycosyltransferase essential for heparan sulfate (HS) biosynthesis. Increasing...

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PMID: 29120519
DOI: 10.1002/jbmr.3341

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