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In vitro attenuation of a virulent swine isolate of Brachyspira hampsonii.

Pathogens and disease - 1 Feb 2018

Perez Jason Byron D S, Fernando Champika, Nosach Roman V, Huang Yanyun, Harding John C S, Hill Janet E

Abstract excerpt

Brachyspira hampsonii causes dysentery-like disease in infected pigs. Serial passage of a virulent swine isolate (P13) one-hundred times in laboratory culture medium was conducted to produce an attenuated strain, and to identify genomic determinants of virulence through comparison of genome sequences of the original and passaged strains. The resulting strain, P113, did not differ from P13 in terms of diagnostic...

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PMID: 29069340
DOI: 10.1093/femspd/ftx116

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