Article
NCCTG N0879 (Alliance): A randomized phase 2 cooperative group trial of carboplatin, paclitaxel, and bevacizumab ± everolimus for metastatic melanoma.
Cancer - 1 Feb 2018
McWilliams Robert R, Allred Jacob B, Slostad Jessica A, Katipamula Rajini, Dronca Roxana S, Rumilla Kandelaria M, Erickson Lori A, Bryce Alan H, Joseph Richard W, Kottschade Lisa A, King David M, Leitch John M, Markovic Svetomir N
Abstract excerpt
BACKGROUND: Despite the success of immune checkpoint and targeted therapy, many patients with melanoma ultimately require further treatment. The combination of carboplatin, paclitaxel, and bevacizumab (CPB) has demonstrated promising activity in a single-arm study. In the current study, the authors performed a randomized phase 2 study to confirm efficacy and to determine whether adding everolimus would increase...
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