Article
F508del CFTR gene mutation in patients with allergic bronchopulmonary aspergillosis.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Aug 2018
Gamaletsou Maria N, Hayes Gemma, Harris Chris, Brock Joanna, Muldoon Eavan G, Denning David W
Abstract excerpt
OBJECTIVE: The F508del mutation occurs in approximately 3.5% of Caucasian population of Northern Europe. Heterozygotes have increased risk for asthma and reduced pulmonary function. Allergic bronchopulmonary aspergillosis (ABPA) is more common in patients with cystic fibrosis (CF). We aimed to establish the frequency of F508del mutation in adult patients with ABPA. METHODS: A retrospective matched case-control...
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