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Article

Generation of iPSC line from desmin-related cardiomyopathy patient carrying splice site mutation of DES gene.

Stem cell research - 1 Oct 2017

Khudiakov Aleksandr, Kostina Daria, Zlotina Anna, Nikulina Tatiana, Sergushichev Alexey, Gudkova Alexandra, Tomilin Alexey, Malashicheva Anna, Kostareva Anna

Abstract excerpt

Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying desmin (DES) gene heterozygous splice site mutation using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. iPSCs were characterized by sequencing, karyotype analysis, STR analysis, immunocytochemistry, RT-PCR and teratoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29034897
DOI: 10.1016/j.scr.2017.08.015

Genes

DES
KLF4
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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