[Establishment of L-periaxin gene knock-out RSC96 cell line].

Abstract excerpt

Periaxin, a protein of noncompact myelin, is specifically expressed in the peripheral nervous system (PNS). There are two protein isoform L-periaxin and S-Periaxin by alternative splicing of periaxin gene, playing an important role in the initiation of myelin formation. So far, 18 different mutation sites in L-periaxin gene have been found to induce the peripheral demyelinating neurological charcot-marie-tooth...

Topics

• Animals
• Cell Line
• Charcot-Marie-Tooth Disease
• Gene Knockout Techniques
• Membrane Proteins
• Mutation
• Protein Isoforms
• Rats