Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis

Abstract excerpt

Chronic pulmonary infection with Pseudomonas aeruginosa that triggers chronic airway inflammation and structural lung damage remains a key risk factor for morbidity and mortality in patients with cystic fibrosis (CF) [1]. Previously, culture-based diagnostics considered airway infections in CF patients as mono-pathogenic, but recent approaches using culture-independent methods showed that bacterial infection of...

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