Article
Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation.
PloS one - 1 Jan 2017
von Volkmann Hilde L, Brønstad Ingeborg, Gilja Odd Helge, R Tronstad Rune, Sangnes Dag Andre, Nortvedt Ragnar, Hausken Trygve, Dimcevski Georg, Fiskerstrand Torunn, Nylund Kim
Abstract excerpt
INTRODUCTION: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C gene encoding GC-C cause Familial GUCY2C diarrhea syndrome (FGDS) which has been diagnosed with severe dysmotility. AIM: To investigate gut motility and hormones before and after a meal in FGDS...
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