Article
Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density.
Metabolism: clinical and experimental - 1 Sept 2017
Weber Thomas J, Koh James, Thomas Samantha M, Hogue Joyce A, Scheri Randall P, Roman Sanziana A, Sosa Julie A
Abstract excerpt
CONTEXT: A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown. OBJECTIVE: We sought to identify new mechanistic indices that could inform more personalized management of PHPT. DESIGN: Pre-, peri-, and postoperative data and...
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