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Article

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.

Disease models & mechanisms - 1 Sept 2017

Savchenko Ekaterina, Singh Yajuvinder, Konttinen Henna, Lejavova Katarina, Mediavilla Santos Laura, Grubman Alexandra, Kärkkäinen Virve, Keksa-Goldsteine Velta, Naumenko Nikolay, Tavi Pasi, White Anthony R, Malm Tarja, Koistinaho Jari, Kanninen Katja M

Abstract excerpt

Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) are the most common group of inherited neurodegenerative diseases that mainly affect children. Pathological features of the NCLs...

Topics

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Calcium
Hippocampus
Interleukin-1beta
Lysosomal Membrane Proteins
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neural Stem Cells

Neuronal Ceroid-Lipofuscinoses

Source

Open in PubMed Open full text

Identifiers

PMID: 28733362
DOI: 10.1242/dmm.029165
PMCID: PMC5611964

Genes

CLN5
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.PMID 28733362Read ↗

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A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brainSemantic proximity Read ↗

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Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in miceSemantic proximity Read ↗

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Induced Pluripotent Stem Cells Derived from a CLN5 Patient Manifest Phenotypic Characteristics of Neuronal Ceroid Lipofuscinoses.Semantic proximity Read ↗

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