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Article

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

28 Jun 2017

Abstract excerpt

values. GS-5734 was also effective against bat CoVs, prepandemic bat CoVs, and circulating contemporary human CoV in primary human lung cells, thus demonstrating broad-spectrum anti-CoV activity. In a mouse model of SARS-CoV pathogenesis, prophylactic and early therapeutic administration of GS-5734 significantly reduced lung viral load and improved clinical signs of disease as well as respiratory function. These...

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PMID: 28659436
DOI: 10.1126/scitranslmed.aal3653

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