Article
The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders.
Molecular autism - 1 Jan 2017
Loth Eva, Charman Tony, Mason Luke, Tillmann Julian, Jones Emily J H, Wooldridge Caroline, Ahmad Jumana, Auyeung Bonnie, Brogna Claudia, Ambrosino Sara, Banaschewski Tobias, Baron-Cohen Simon, Baumeister Sarah, Beckmann Christian, Brammer Michael, Brandeis Daniel, Bölte Sven, Bourgeron Thomas, Bours Carsten, de Bruijn Yvette, Chakrabarti Bhismadev, Crawley Daisy, Cornelissen Ineke, Acqua Flavio Dell', Dumas Guillaume, Durston Sarah, Ecker Christine, Faulkner Jessica, Frouin Vincent, Garces Pilar, Goyard David, Hayward Hannah, Ham Lindsay M, Hipp Joerg, Holt Rosemary J, Johnson Mark H, Isaksson Johan, Kundu Prantik, Lai Meng-Chuan, D'ardhuy Xavier Liogier, Lombardo Michael V, Lythgoe David J, Mandl René, Meyer-Lindenberg Andreas, Moessnang Carolin, Mueller Nico, O'Dwyer Laurence, Oldehinkel Marianne, Oranje Bob, Pandina Gahan, Persico Antonio M, Ruigrok Amber N V, Ruggeri Barbara, Sabet Jessica, Sacco Roberto, Cáceres Antonia San José, Simonoff Emily, Toro Roberto, Tost Heike, Waldman Jack, Williams Steve C R, Zwiers Marcel P, Spooren Will, Murphy Declan G M, Buitelaar Jan K
Abstract excerpt
BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be...
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