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Article

Three-dimensional Sphere-forming Cells Are Unique Multipotent Cell Population in Dental Pulp Cells.

Journal of endodontics - 1 Aug 2017

Lee Sung Hee, Inaba Andrew, Mohindroo Neha, Ganesh Deepika, Martin Charlotte Ellen, Chugal Nadia, Kim Reuben H, Kang Mo K, Park No-Hee, Shin Ki-Hyuk

Abstract excerpt

INTRODUCTION: Mesenchymal stem cells (MSCs) are typically cultured as adherent monolayer using a conventional tissue culture technique. However, this technique incompletely reproduces an in vivo microenvironment of stem cells and results in the loss of stemness properties. Three-dimensional (3D) sphere culture is one of the most widely used 3D culture techniques that have been developed to recapitulate the...

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PMID: 28606672
DOI: 10.1016/j.joen.2017.03.016

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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