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Article

Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy.

Scientific reports - 6 Jun 2017

Feyaerts Dorien, Benner Marilen, van Cranenbroek Bram, van der Heijden Olivier W H, Joosten Irma, van der Molen Renate G

Abstract excerpt

Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on the transition of pre-pregnancy endometrial lymphocytes to a pregnancy state. Here, we immunophenotyped lymphocytes from endometrium (MMC), term decidua parietalis (DPMC), and PBMC for direct comparison. We found that the immune cell...

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Identifiers

PMID: 28588205
DOI: 10.1038/s41598-017-03191-0
PMCID: PMC5460245

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