Article
A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2017
Ke E-E, Zhou Qing, Zhang Qiu-Yi, Su Jian, Chen Zhi-Hong, Zhang Xu-Chao, Xu Chong-Rui, Yang Jin-Ji, Tu Hai-Yan, Yan Hong-Hong, Zhang Yi-Chen, Niu Fei-Yu, Wu Yi-Long
Abstract excerpt
INTRODUCTION: Increasing evidence has demonstrated that exon 19 deletions (Del19) and L858R mutation in EGFR have different prognostic and predictive roles in NSCLC. We aimed to investigate whether these two mutations produced differences in mechanisms of resistance to EGFR tyrosine kinase inhibitors. METHODS: Consecutive patients with advanced EGFR-mutant NSCLC who acquired resistance to EGFR tyrosine kinase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.