Article
The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.
Molecular cell - 1 Jun 2017
Zhu Jia-Ying, Li Yuyao, Cao Dong-Mei, Yang Hongjuan, Oh Eunkyoo, Bi Yang, Zhu Shengwei, Wang Zhi-Yong
Abstract excerpt
The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In Arabidopsis, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated brassinosteroid (BR) signaling. Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes...
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