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Article

Pediatric Cancer Predisposition and Surveillance: An Overview, and a Tribute to Alfred G. Knudson Jr.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2017

Brodeur Garrett M, Nichols Kim E, Plon Sharon E, Schiffman Joshua D, Malkin David

Abstract excerpt

The prevalence of childhood cancer attributable to genetic predisposition was generally considered very low. However, recent reports suggest that at least 10% of pediatric cancer patients harbor a germline mutation in a cancer predisposition gene. Although some of these children will have a family history suggestive of a cancer predisposition syndrome, many others will not. Evidence from recent pediatric studies...

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Identifiers

PMID: 28572261
DOI: 10.1158/1078-0432.CCR-17-0702
PMCID: PMC5553563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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