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Article

Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis.

PloS one - 1 Jan 2017

Zwingerman Nora, Medina-Rivera Alejandra, Kassam Irfahan, Wilson Michael D, Morange Pierre-Emmanuel, Trégouët David-Alexandre, Gagnon France

Abstract excerpt

BACKGROUND: Thrombin activatable fibrinolysis inhibitor (TAFI), encoded by the Carboxypeptidase B2 gene (CPB2), is an inhibitor of fibrinolysis and plays a role in the pathogenesis of venous thrombosis. Experimental findings support a functional role of genetic variants in CPB2, while epidemiological studies have been unable to confirm associations with risk of venous thrombosis. Sex-specific effects could...

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Identifiers

PMID: 28552956
DOI: 10.1371/journal.pone.0177768
PMCID: PMC5446132

Genes

CPB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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