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Article

Utility of Genomic Assessment of Blood-Derived Circulating Tumor DNA (ctDNA) in Patients with Advanced Lung Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2017

Schwaederlé Maria C, Patel Sandip P, Husain Hatim, Ikeda Megumi, Lanman Richard B, Banks Kimberly C, Talasaz AmirAli, Bazhenova Lyudmila, Kurzrock Razelle

Abstract excerpt

Purpose: Genomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with non-small cell lung adenocarcinoma (NSCLC) were ascertained and correlated with clinical characteristics and therapeutic outcomes.Experimental Design: Comprehensive plasma ctDNA testing was performed in 88 consecutive patients; 34 also had tissue next-generation sequencing; 29, other forms of genotyping; and 25 (28.4%)...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Circulating Tumor DNA
Clinical Trials as Topic
Female
Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomics

Genotype

High-Throughput Nucleotide Sequencing

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 28539465
DOI: 10.1158/1078-0432.CCR-16-2497
PMCID: PMC5581668

Genes

EGFR
ALK
KRAS
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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