Article
IFT81 as a Candidate Gene for Nonsyndromic Retinal Degeneration.
Investigative ophthalmology & visual science - 1 May 2017
Dharmat Rachayata, Liu Wei, Ge Zhongqi, Sun Zixi, Yang Lizhu, Li Yumei, Wang Keqing, Thomas Kandace, Sui Ruifang, Chen Rui
Abstract excerpt
Purpose: IFT81, a core component of the IFT-B complex, involved in the bidirectional transport of ciliary proteins, has been recently implicated in syndromic ciliopathies. However, none of the IFT-B core complex proteins have been associated with nonsyndromic retinal dystrophies. Given the import...
Topics
- Animals
- Cells, Cultured
- Codon, Nonsense
- DNA
- DNA Mutational Analysis
- Disease Models, Animal
- Female
- Humans
- Male
- Muscle Proteins
- Mutation
- Phenotype
- Retina
- Retinal Degeneration
- Zebrafish