Article
The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.
Cancer letters - 1 Aug 2017
Lu Jiaxiong, Guan Shan, Zhao Yanling, Yu Yang, Woodfield Sarah E, Zhang Huiyuan, Yang Kristine L, Bieerkehazhi Shayahati, Qi Lin, Li Xiaonan, Gu Jerry, Xu Xin, Jin Jingling, Muscal Jodi A, Yang Tianshu, Xu Guo-Tong, Yang Jianhua
Abstract excerpt
Activating germline mutations of anaplastic lymphoma kinase (ALK) occur in most cases of hereditary neuroblastoma (NB) and the constitutively active kinase activity of ALK promotes cell proliferation and survival in NB. Therefore, ALK kinase is a potential therapeutic target for NB. In this study, we show that the novel ALK inhibitor alectinib effectively suppressed cell proliferation and induces apoptosis in NB...
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