Article
Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria.
eLife - 27 Apr 2017
Pankey M Sabrina, Foxall Randi L, Ster Ian M, Perry Lauren A, Schuster Brian M, Donner Rachel A, Coyle Matthew, Cooper Vaughn S, Whistler Cheryl A
Abstract excerpt
Host immune and physical barriers protect against pathogens but also impede the establishment of essential symbiotic partnerships. To reveal mechanisms by which beneficial organisms adapt to circumvent host defenses, we experimentally evolved ecologically distinct bioluminescent Vibrio fischeri by colonization and growth within the light organs of the squid Euprymna scolopes. Serial squid passaging of bacteria...
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