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Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors

4 Apr 2017

Abstract excerpt

Inflammasome signalling induces the processing and secretion of interleukin (IL)-1β and IL-18 which, coupled with pyroptosis, activate further the inflammatory response. In the present study we evaluated the expression of genes involved in inflammasome signalling pathways in septic patients, their interaction networks and the predicted functions modulated in survivors and non-survivors. Twenty-seven patients with...

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PMID: 28369745
DOI: 10.1111/cei.12971

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