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The APPLE Trial: Feasibility and Activity of AZD9291 (Osimertinib) Treatment on Positive PLasma T790M in EGFR-mutant NSCLC Patients. EORTC 1613.

Clinical lung cancer - 1 Sept 2017

Remon Jordi, Menis Jessica, Hasan Baktiar, Peric Aleksandra, De Maio Eleonora, Novello Silvia, Reck Martin, Berghmans Thierry, Wasag Bartosz, Besse Benjamin, Dziadziuszko Rafal

Abstract excerpt

The AZD9291 (Osimertinib) Treatment on Positive PLasma T790M in EGFR-mutant NSCLC Patients (APPLE) trial is a randomized, open-label, multicenter, 3-arm, phase II study in advanced, epidermal growth factor receptor (EGFR)-mutant and EGFR tyrosine kinase inhibitor (TKI)-naive non-small-cell lung cancer (NSCLC) patients, to evaluate the best strategy for sequencing gefitinib and osimertinib treatment. Advanced...

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Identifiers

PMID: 28341106
DOI: 10.1016/j.cllc.2017.02.005

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The APPLE Trial: Feasibility and Activity of AZD9291 (Osimertinib) Treatment on Positive PLasma T790M in EGFR-mutant NSCLC Patients. EORTC 1613.PMID 28341106Read ↗

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