Article
EGFR TKI combination with immunotherapy in non-small cell lung cancer.
Expert opinion on drug safety - 1 Apr 2017
Ahn Myung-Ju, Sun Jong-Mu, Lee Se-Hoon, Ahn Jin Seok, Park Keunchil
Abstract excerpt
INTRODUCTION: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) has significantly improved clinical outcomes compared with chemotherapy in non-small cell lung cancer (NSCLC) patients with sensitizing EGFR gene mutation. Areas covered: Almost all patients treated with EGFR TKIs eventually develop acquired resistance. It has been reported that activation of the oncogenic EGFR pathway enhances...
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