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Article

Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells.

Apoptosis : an international journal on programmed cell death - 1 Jun 2017

Lewinska Anna, Adamczyk-Grochala Jagoda, Kwasniewicz Ewa, Deregowska Anna, Wnuk Maciej

Abstract excerpt

Plant-derived pentacyclic triterpenotids with multiple biological activities are considered as promising candidates for cancer therapy and prevention. However, their mechanisms of action are not fully understood. In the present study, we have analyzed the effects of low dose treatment (5-20 µM) of ursolic acid (UA) and betulinic acid (BA) on breast cancer cells of different receptor status, namely MCF-7 (ER+,...

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PMID: 28213701
DOI: 10.1007/s10495-017-1353-7
PMCID: PMC5401707

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