Article
GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis.
Science (New York, N.Y.) - 17 Feb 2017
Yang Xinxing, Lyu Zhixin, Miguel Amanda, McQuillen Ryan, Huang Kerwyn Casey, Xiao Jie
Abstract excerpt
The bacterial tubulin FtsZ is the central component of the cell division machinery, coordinating an ensemble of proteins involved in septal cell wall synthesis to ensure successful constriction. How cells achieve this coordination is unknown. We found that in Escherichia coli cells, FtsZ exhibits dynamic treadmilling predominantly determined by its guanosine triphosphatase activity. The treadmilling dynamics...
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