Article
A novel murine model of esophageal nonerosive reflux disease: from inflammation to impairment in mucosal integrity.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2017
Silva Renan O, Oliveira Francisco Fábio B, Bingana Rudy D, Arruda Mailton O, Woodland Philip, Lee Chung, Souza Miguel A N, Soares Pedro M G, Santos Armênio A, Sifrim Daniel, Souza Marcellus H L P
Abstract excerpt
Nonerosive reflux disease (NERD) is a highly prevalent phenotype of the gastroesophageal reflux disease. In this study, we developed a novel murine model of NERD in mice with microscopic inflammation and impairment in the epithelial esophageal barrier. Female Swiss mice were subjected to the following surgical procedure: the transitional region between the forestomach and the glandular portion of the stomach was...
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